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Highly efficient near-infrared BODIPY phototherapeutic nanoparticles for cancer treatment

Yuandong Zhang(a) Zhiyu Yang(a) Xiaohua Zheng(b) Li Chen(a) and Zhigang Xie(b)

(a) Department of Chemistry, Northeast Normal University, 5268 Renmin Street, Changchun, P. R. China 
(b) State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun, P. R. China

Reference: J. Mater. Chem. B, 2020, 8, 5305-5311. https://doi.org/10.1039/D0TB00991A 

Abstract

  • BODIPYs are highly potential photoactive agents for cancer theragnostics. The rational design of BODIPYbased photoactive nanodrugs with high efficiency and near-infrared (NIR) absorption is imperative.
  • A donor–acceptor–donor (D–A–D) organic photosensitizer (PS) (BODIPY, named NBB), which possessed strong absorption in the NIR region due to the multi-intersection of intramolecular charge transfer (ICT), photoinduced electron transfer (PET), and heavy atom effects. 
  • Through a nanoprecipitation method, NBB nanoparticles (NPs) were facilely prepared. The as-prepared NBB NPs exhibited favorable water-stability and photostability.
  • The outstanding photon absorption capacity endows the NPs with high photothermal conversion efficiency (Z = 53.8%) and active singlet oxygen (1O2) generation ability upon 808 nm laser irradiation.
     

 Materials & Devices

 *Figure reference: J. Mater. Chem. B, 2020, 8, 5305-5311. https://doi.org/10.1039/D0TB00991A

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