A Highly Selective NIR Fluorescent Turn-on Probe for Hydroxyl Radical and Its Application in Living Cell Images

Xingyu Qu(1,2), Wenting Song(1) and Zhen Shen(1)

(1) State Key Laboratory of Coordination Chemistry, Nanjing National Laboratory of Microstructures, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China
(2) Department of Chemistry and Chemical Engineering, Jinzhong University, Jinzhong, China

Reference: Front. Chem., 28 August 2019. 


  • A highly selective NIR fluorescent turn-on probe for hydroxyl radical (·OH) has been built up using triphenylphosphine as a reactive-site for ·OH in an energy transfer cassette 2b consisting of 8-2'-(thiophen-2-yl) quinoline (TQ) as a donor and 3,5-diphenylphosphinostyryl-substituted BODIPY as an acceptor, which exhibits ca. 317 nm pseudo Stokes’ shift due to efficient through-bond energy transfer (up to 169%).
  • The triphenylphosphine substituent of 2b selectively oxidized by ·OH over the other reactive oxygen species (ROS) and the reactive nitrogen species (RNS) resulting in fluorescence enhancement in aqueous solution and in living cells.

Materials & Devices

BODIPY Dyes,ox-2b

BODIPY Dyes,ox-2b

Figure reference: Front. Chem., 28 August 2019.


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